Evaluation of the marker of hypercoagulability prothrombin fragment F 1+2 in patients with mechanical or biological heart valve prostheses.

نویسندگان

  • Claudia Natália Ferreira
  • Lauro Mello Vieira
  • Luci Maria Sant'Ana Dusse
  • Carlos Faria Santos Amaral
  • William Antônio de Magalhães Esteves
  • Lúcia Maria Amorim Fenelon
  • Maria das Graças Carvalho
چکیده

OBJECTIVE To investigate whether patients with heart valve prostheses and similar International Normalized Ratios (INR) have the same level of protection against thromboembolic events, that is, whether the anticoagulation intensity is related to the intensity of hypercoagulability suppression. METHODS INR and plasma levels of prothrombin fragment 1+2 (F1+2) were assessed in blood samples of 27 patients (7 with mechanical heart valves and 20 with biological heart valves) and 27 blood samples from healthy donors that were not taking any medication. RESULTS Increased levels of F1+2 were observed in blood samples of 5 patients with heart valve prostheses taking warfarin. These findings reinforce the idea that even though patients may have INRs, within the therapeutic spectrum, they are not free from new thromboembolic events. CONCLUSION Determination of the hypercoagulability marker F1+2 might result in greater efficacy and safety for the use of oral anticoagulants, resulting in improved quality of life for patients.

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عنوان ژورنال:
  • Arquivos brasileiros de cardiologia

دوره 79 5  شماره 

صفحات  -

تاریخ انتشار 2002